The Antinociceptive Efficacy of HWTX-I Epidurally Administered in Rheumatoid Arthritis Rats

Z. Wen tao; T. Gu yang; R. Ying; W. Mao cai; L. Lin; L. Chi miao; H. Peng; C. Jia Qin

doi:10.1055/s-0031-1280775

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2011; 32(11): 869-874
DOI: 10.1055/s-0031-1280775

Clinical Sciences

Georg Thieme Verlag KG Stuttgart · New York

The Antinociceptive Efficacy of HWTX-I Epidurally Administered in Rheumatoid Arthritis Rats

Z. Wen tao

¹Hunan Normal University, College of Physical Education, Changsha, China

³Hunan Supervision and Inspection Institute for Product Quality, Changsha, China

,

T. Gu yang

¹Hunan Normal University, College of Physical Education, Changsha, China

,

R. Ying

¹Hunan Normal University, College of Physical Education, Changsha, China

,

W. Mao cai

¹Hunan Normal University, College of Physical Education, Changsha, China

,

L. Lin

¹Hunan Normal University, College of Physical Education, Changsha, China

,

L. Chi miao

²Central Hospital of Shaoyang, Shaoyang, China

,

H. Peng

¹Hunan Normal University, College of Physical Education, Changsha, China

,

C. Jia Qin

¹Hunan Normal University, College of Physical Education, Changsha, China

› Author Affiliations

Abstract

Rheumatoid arthritis (RA) is one of the inflammatory kinds of arthritis in the clinical situation, and cytosolic Ca²⁺ overload has been proposed as one of the primary factors for many inflammatory cells activation, which lead to relative enzymes and inflammatory factors release. It is therefore accepted that Ca²⁺ channel blockers can protect joint injury from inflammation. In the present study we investigated the possible molecular mechanism of the antinociceptive efficacy of HWTX-I, a spider peptide toxin blocking Ca²⁺ channels, on the rat rheumatoid arthritis model. Our study demonstrates that HWTX-I can relieve pain in the inflammatory joints and eliminate arthrocele to some degree. Moreover, HWTX-I can also decrease the concentration of tumour necrosis factor α (TNF-α) and increase the concentration of interleukin 4(IL-4) and interleukin 10(IL-10) in rat’s serum. HWTX-I can also decrease the mRNA expression level of related factors of TNF-α, interleukin 1β (IL-1β) and interleukin 6(IL-6) in inflammatory pathways in rheumatoid arthritis. Therefore, the present results show that the epidural administration of HWTX-I is effective in antinociception in the rat model of rheumatoid arthritis, which may act through its inhibition on certain inflammatory pathways.

Key words

HWTX-I - rheumatoid arthritis - calcium channel blocker - antinociception

Full Text

References

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